Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 2.565


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXB6chr17_-_466823330.461.1e-02Click!
HOXA6chr7_-_271873670.383.7e-02Click!
HOXA7chr7_-_271961630.374.4e-02Click!
HOXB7chr17_-_466883620.374.6e-02Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_31352489 22.412 NM_001253827
 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr17_-_38859976 20.426 NM_019016
 KRT24
keratin 24
chr1_+_84630575 19.545 NM_001242860
NM_001242861
 PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr7_-_41742666 15.974 NM_002192
 INHBA
inhibin, beta A
chr2_-_161056573 15.812 NM_000888
 ITGB6
integrin, beta 6
chr13_-_60325073 15.728


chrX_+_135251795 15.229 NM_001167819
 FHL1
four and a half LIM domains 1
chr1_-_205391180 15.085 NM_001001552
NM_001199050
NM_001199051
NM_001199052
 LEMD1



LEM domain containing 1



chr2_-_216259197 15.006 FN1
fibronectin 1
chr2_+_102508377 13.763 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_210444364 13.184 NM_002374
NM_031845
NM_031847
 MAP2


microtubule-associated protein 2


chr1_+_84630014 12.919 NM_001242857
NM_001242858
NM_001242859
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr6_+_34206567 12.763 NM_145905
 HMGA1
high mobility group AT-hook 1
chr2_+_102508333 12.379 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr4_+_169013687 12.312 NM_007193
 ANXA10
annexin A10
chrX_+_135251454 12.280 NM_001159704
 FHL1
four and a half LIM domains 1
chr1_+_151032866 12.139 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032683 12.073 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 11.746 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr2_-_216241321 11.398 FN1
fibronectin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 137 entries
enrichment   p-value GO term description
3.49 7.46e-05 GO:0007602 phototransduction
3.49 3.94e-04 GO:0009954 proximal/distal pattern formation
2.99 2.98e-03 GO:0071363 cellular response to growth factor stimulus
2.97 1.83e-03 GO:0009583 detection of light stimulus
2.87 5.94e-05 GO:0070848 response to growth factor stimulus
2.35 3.08e-02 GO:0009582 detection of abiotic stimulus
2.21 8.16e-07 GO:0045165 cell fate commitment
2.21 2.74e-02 GO:2000027 regulation of organ morphogenesis
2.07 1.17e-02 GO:0042176 regulation of protein catabolic process
1.90 2.38e-02 GO:0030162 regulation of proteolysis
1.86 1.59e-02 GO:0034330 cell junction organization
1.86 4.88e-02 GO:0034329 cell junction assembly
1.84 9.82e-03 GO:0009952 anterior/posterior pattern formation
1.82 1.30e-04 GO:0003002 regionalization
1.82 2.22e-04 GO:0007601 visual perception
1.82 2.22e-04 GO:0050953 sensory perception of light stimulus
1.82 3.76e-02 GO:0009416 response to light stimulus
1.74 1.86e-02 GO:0007517 muscle organ development
1.71 4.77e-02 GO:0048732 gland development
1.70 9.37e-04 GO:0061061 muscle structure development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
2.51 3.55e-03 GO:0034774 secretory granule lumen
2.45 9.04e-03 GO:0031093 platelet alpha granule lumen
2.41 8.33e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.32 1.83e-02 GO:0031983 vesicle lumen
2.30 1.00e-02 GO:0031091 platelet alpha granule
2.11 4.66e-03 GO:0045095 keratin filament
1.99 2.30e-03 GO:0030055 cell-substrate junction
1.86 1.01e-03 GO:0005912 adherens junction
1.86 3.50e-02 GO:0005924 cell-substrate adherens junction
1.85 2.05e-02 GO:0044420 extracellular matrix part
1.83 5.48e-04 GO:0005882 intermediate filament
1.81 1.22e-03 GO:0070161 anchoring junction
1.75 1.30e-06 GO:0005578 proteinaceous extracellular matrix
1.69 7.67e-04 GO:0016323 basolateral plasma membrane
1.69 4.60e-03 GO:0045111 intermediate filament cytoskeleton
1.67 2.52e-06 GO:0031012 extracellular matrix
1.67 2.33e-02 GO:0030424 axon
1.58 8.97e-04 GO:0044433 cytoplasmic vesicle part
1.54 7.33e-07 GO:0030054 cell junction
1.54 3.57e-04 GO:0045202 synapse

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
2.32 3.20e-02 GO:0051015 actin filament binding
1.72 3.56e-14 GO:0043565 sequence-specific DNA binding
1.63 1.12e-02 GO:0046982 protein heterodimerization activity
1.57 2.48e-03 GO:0003779 actin binding
1.55 7.67e-07 GO:0005198 structural molecule activity
1.52 2.98e-11 GO:0030528 transcription regulator activity
1.50 4.34e-10 GO:0001071 nucleic acid binding transcription factor activity
1.50 4.34e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 3.86e-07 GO:0005102 receptor binding
1.39 1.79e-02 GO:0008092 cytoskeletal protein binding
1.12 4.57e-07 GO:0005515 protein binding
1.05 4.07e-02 GO:0005488 binding