Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 2.565


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXB6chr17_-_466823330.461.1e-02Click!
HOXA6chr7_-_271873670.383.7e-02Click!
HOXA7chr7_-_271961630.374.4e-02Click!
HOXB7chr17_-_466883620.374.6e-02Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_31352489 22.412 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr17_-_38859976 20.426 NM_019016
KRT24
keratin 24
chr1_+_84630575 19.545 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr7_-_41742666 15.974 NM_002192
INHBA
inhibin, beta A
chr2_-_161056573 15.812 NM_000888
ITGB6
integrin, beta 6
chr13_-_60325073 15.728


chrX_+_135251795 15.229 NM_001167819
FHL1
four and a half LIM domains 1
chr1_-_205391180 15.085 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr2_-_216259197 15.006 FN1
fibronectin 1
chr2_+_102508377 13.763 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_210444364 13.184 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr1_+_84630014 12.919 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr6_+_34206567 12.763 NM_145905
HMGA1
high mobility group AT-hook 1
chr2_+_102508333 12.379 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr4_+_169013687 12.312 NM_007193
ANXA10
annexin A10
chrX_+_135251454 12.280 NM_001159704
FHL1
four and a half LIM domains 1
chr1_+_151032866 12.139 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032683 12.073 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 11.746 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr2_-_216241321 11.398 FN1
fibronectin 1
chr4_+_69313166 11.258 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr2_-_161056762 10.785 ITGB6
integrin, beta 6
chrX_+_135278912 10.150 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr8_+_54764367 9.989 NM_170587
RGS20
regulator of G-protein signaling 20
chr3_-_57234279 9.873 NM_003865
HESX1
HESX homeobox 1
chr13_-_103719195 9.785 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr7_-_83824216 9.209 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr15_-_70390226 9.016 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr2_-_216003068 8.947 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr1_+_84630374 8.537 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_-_89745997 8.437 DUSP6
dual specificity phosphatase 6
chr15_+_93443559 8.267 CHD2
chromodomain helicase DNA binding protein 2
chr4_-_159093523 8.214 FAM198B
family with sequence similarity 198, member B
chr2_-_215896809 7.972 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr12_-_89746238 7.903 DUSP6
dual specificity phosphatase 6
chr7_+_134576187 7.725 CALD1
caldesmon 1
chr17_-_39093671 7.661 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr12_-_122240827 7.571


chr12_-_28124915 7.350 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr5_-_88119604 7.282 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_+_168250277 7.269 NM_005149
TBX19
T-box 19
chr12_-_89746244 7.105 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr15_-_70390229 7.077 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr17_-_39092714 6.927 KRT23
keratin 23 (histone deacetylase inducible)
chr10_+_17270257 6.865 NM_003380
VIM
vimentin
chr7_-_14025826 6.782 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr2_+_210444154 6.541 MAP2
microtubule-associated protein 2
chr13_-_36050758 6.540 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr10_+_118187381 6.481 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr2_+_54785453 6.429 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr16_+_82660390 6.382 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr18_+_29027731 6.370 NM_001944
DSG3
desmoglein 3
chr4_-_47983430 6.347 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr1_+_183114214 6.316 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr12_+_105153258 5.993 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr15_+_71839540 5.920 THSD4
thrombospondin, type I, domain containing 4
chr7_+_134576150 5.910 NM_033139
NM_033140
CALD1

caldesmon 1

chr3_-_74570262 5.894 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr7_+_134464161 5.894 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr7_+_134464372 5.799 CALD1
caldesmon 1
chr4_-_68749698 5.728 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr6_+_100054649 5.681 NM_021620
PRDM13
PR domain containing 13
chr2_-_165424993 5.637 GRB14
growth factor receptor-bound protein 14
chr2_+_182850550 5.588 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr11_+_113775517 5.562 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr17_-_10452939 5.459 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr3_-_196911001 5.432 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr11_-_16424391 5.396 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr7_+_134464417 5.370 CALD1
caldesmon 1
chr3_+_158787040 5.260 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr13_-_20805371 5.138 NM_006783
GJB6
gap junction protein, beta 6, 30kDa
chr7_+_18535351 5.113 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr1_-_152386727 5.106 NM_016190
CRNN
cornulin
chr4_-_41750936 5.026 NM_003924
PHOX2B
paired-like homeobox 2b
chr3_+_159557745 5.021 SCHIP1
schwannomin interacting protein 1
chrX_+_28605558 4.984 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr18_-_31628557 4.982 NM_001198549
NOL4
nucleolar protein 4
chr7_+_139528951 4.920 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr2_+_33359607 4.898 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr3_+_159557649 4.876 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr18_+_33234532 4.875 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr8_+_32504250 4.797 NM_013959
NRG1
neuregulin 1
chr14_-_57277096 4.781 NM_021728
OTX2
orthodenticle homeobox 2
chr7_+_28452143 4.734 NM_182898
CREB5
cAMP responsive element binding protein 5
chr15_+_93443418 4.730 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr1_+_84647342 4.679 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_211458078 4.627 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr1_-_27732069 4.623 WASF2
WAS protein family, member 2
chrX_+_85517970 4.601 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr3_-_149095333 4.518 TM4SF1
transmembrane 4 L six family member 1
chr4_-_123377471 4.508 NM_000586
IL2
interleukin 2
chr6_-_131321868 4.503 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr12_-_102512277 4.490 NM_024057
NUP37
nucleoporin 37kDa
chr7_-_27205148 4.476 NM_152739
HOXA9
homeobox A9
chr6_+_130339715 4.459 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr18_+_56530060 4.428 NM_018181
ZNF532
zinc finger protein 532
chr16_+_7382750 4.417 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr7_-_107443631 4.389 NM_000111
SLC26A3
solute carrier family 26, member 3
chr6_+_64286348 4.377 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr13_-_46425756 4.359 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr3_+_130569368 4.355 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr1_+_63063186 4.306 NM_014495
ANGPTL3
angiopoietin-like 3
chr2_-_190044330 4.290 NM_000393
COL5A2
collagen, type V, alpha 2
chr2_-_190927321 4.245 NM_005259
MSTN
myostatin
chr4_-_176733413 4.245 GPM6A
glycoprotein M6A
chr3_+_12392993 4.236 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr3_-_149095458 4.208 TM4SF1
transmembrane 4 L six family member 1
chr3_-_149095517 4.196 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr12_-_10978867 4.195 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr12_+_15699277 4.180 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr7_+_80275967 4.174 CD36
CD36 molecule (thrombospondin receptor)
chr4_+_74269971 4.166 NM_000477
ALB
albumin
chr1_+_115572414 4.151 NM_000549
TSHB
thyroid stimulating hormone, beta
chr3_-_149095413 4.095 TM4SF1
transmembrane 4 L six family member 1
chr4_-_40936640 4.084 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr2_-_2334887 4.047 NM_015025
MYT1L
myelin transcription factor 1-like
chr21_+_30517897 4.035 C21orf7
chromosome 21 open reading frame 7
chr15_-_80263460 4.009 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr10_-_14372807 4.001 NM_018027
FRMD4A
FERM domain containing 4A
chr19_-_50143350 3.996 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr12_+_119616594 3.989 NM_014365
HSPB8
heat shock 22kDa protein 8
chr12_-_71031174 3.975 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr4_-_57547845 3.966 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr17_-_9694613 3.937 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr5_+_166711842 3.933 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr12_+_21525801 3.903 NM_000415
IAPP
islet amyloid polypeptide
chr12_-_99548867 3.897 NM_001204067
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chrX_-_15683153 3.889 NM_020665
TMEM27
transmembrane protein 27
chr1_-_197036350 3.875 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr6_-_66417069 3.849 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chrM_-_9203 3.831


chr1_+_84609941 3.825 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_-_119599253 3.823 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr2_-_55237255 3.783 NM_007008
RTN4
reticulon 4
chr9_+_118916069 3.769 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chrX_-_18690187 3.762 NM_000330
RS1
retinoschisin 1
chr3_+_156394452 3.725 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr21_+_39628869 3.710 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr10_-_105845619 3.700 NM_000494
COL17A1
collagen, type XVII, alpha 1
chrX_-_107682600 3.679 NM_001847
COL4A6
collagen, type IV, alpha 6
chr2_+_158114109 3.669 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr7_-_27205123 3.645 HOXA9
homeobox A9
chr8_-_95449131 3.625 NM_001205263
RAD54B
RAD54 homolog B (S. cerevisiae)
chr15_-_34610928 3.619 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr1_+_74701070 3.618 NM_015978
TNNI3K
TNNI3 interacting kinase
chr4_+_88529680 3.613 NM_014208
DSPP
dentin sialophosphoprotein
chr22_-_36236264 3.605 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr4_-_2230957 3.576 NM_181808
POLN
polymerase (DNA directed) nu
chr10_+_102123420 3.573


chr1_+_50574601 3.563 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_92918924 3.537 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr8_-_91094924 3.534 NM_004929
CALB1
calbindin 1, 28kDa
chr17_-_46622274 3.524 NM_002145
HOXB2
homeobox B2
chr11_+_5410606 3.459 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr14_-_57272344 3.434 NM_172337
OTX2
orthodenticle homeobox 2
chr3_-_50340979 3.431 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr15_-_56209305 3.412 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr17_-_49124128 3.389 NM_001251971
SPAG9
sperm associated antigen 9
chr10_-_105845556 3.369 COL17A1
collagen, type XVII, alpha 1
chr3_-_119582422 3.345 GSK3B
glycogen synthase kinase 3 beta
chrX_+_91090459 3.344 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr3_-_71778268 3.342 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr16_+_8806825 3.325 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr1_+_152956563 3.316 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr7_+_110731061 3.303 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr12_-_53994783 3.300 NM_001130059
ATF7
activating transcription factor 7
chr12_-_52779362 3.270 NM_033045
KRT84
keratin 84
chr2_-_167005641 3.267 NM_001202435
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr3_-_167191808 3.266 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr14_+_51955854 3.263 NM_001042481
FRMD6
FERM domain containing 6
chr13_+_32313678 3.238 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr8_+_66582107 3.223 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr9_-_95244634 3.208 ASPN
asporin
chr4_-_159093717 3.203 NM_016613
FAM198B
family with sequence similarity 198, member B
chr17_-_64225496 3.182 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr22_-_36236421 3.181 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr9_+_125033126 3.168 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr8_+_9953061 3.158 NM_001135671
NM_001199729
MSRA

methionine sulfoxide reductase A

chr7_-_107643330 3.135 NM_002291
LAMB1
laminin, beta 1
chr12_-_102874340 3.081 IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_+_45296053 3.065 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr2_-_122159140 3.042 CLASP1
cytoplasmic linker associated protein 1
chr3_-_101039403 3.001 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr1_-_244006471 2.995 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr14_+_62462540 2.993 NM_031914
SYT16
synaptotagmin XVI
chr11_-_128457452 2.968 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr9_+_12693385 2.941 NM_000550
TYRP1
tyrosinase-related protein 1
chr10_+_17270469 2.937 VIM
vimentin
chr11_+_124735281 2.935 NM_022370
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr1_+_209878135 2.933 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr4_-_39033981 2.917 NM_024943
TMEM156
transmembrane protein 156
chr6_-_155777036 2.896 NM_015718
NOX3
NADPH oxidase 3
chr2_-_31637598 2.887 NM_000379
XDH
xanthine dehydrogenase
chr6_-_10415438 2.886 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr20_-_10654139 2.884 JAG1
jagged 1
chr9_+_27109138 2.858 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr17_-_46682333 2.852 NM_018952
HOXB6
homeobox B6
chr16_+_82660573 2.842 CDH13
cadherin 13, H-cadherin (heart)
chr9_-_95244750 2.828 NM_001193335
NM_017680
ASPN

asporin

chrX_+_99839789 2.816 NM_022144
TNMD
tenomodulin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 7.17e-24 GO:0032502 developmental process
1.37 1.72e-22 GO:0007275 multicellular organismal development
1.39 2.62e-22 GO:0048856 anatomical structure development
1.27 2.11e-21 GO:0032501 multicellular organismal process
1.40 3.18e-21 GO:0048731 system development
1.44 1.40e-15 GO:0048513 organ development
1.49 1.97e-14 GO:0009653 anatomical structure morphogenesis
1.15 2.06e-12 GO:0065007 biological regulation
1.37 2.89e-11 GO:0030154 cell differentiation
1.35 1.24e-10 GO:0048869 cellular developmental process
1.15 2.98e-10 GO:0050789 regulation of biological process
1.16 3.65e-10 GO:0050794 regulation of cellular process
1.42 5.70e-10 GO:0007399 nervous system development
1.60 1.74e-09 GO:0010557 positive regulation of macromolecule biosynthetic process
1.55 2.13e-09 GO:0009891 positive regulation of biosynthetic process
1.55 3.71e-09 GO:0031328 positive regulation of cellular biosynthetic process
1.23 4.18e-09 GO:0023052 signaling
1.16 7.30e-09 GO:0050896 response to stimulus
1.51 1.54e-08 GO:0050793 regulation of developmental process
1.27 2.70e-08 GO:0048518 positive regulation of biological process
1.48 3.73e-08 GO:0009605 response to external stimulus
1.23 5.86e-08 GO:0007165 signal transduction
1.58 7.13e-08 GO:0045595 regulation of cell differentiation
1.41 1.10e-07 GO:0009893 positive regulation of metabolic process
1.61 1.18e-07 GO:0009887 organ morphogenesis
1.08 2.01e-07 GO:0009987 cellular process
1.59 2.08e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.50 2.24e-07 GO:0009888 tissue development
1.56 2.58e-07 GO:0010628 positive regulation of gene expression
1.42 2.89e-07 GO:0010604 positive regulation of macromolecule metabolic process
1.28 3.44e-07 GO:0048519 negative regulation of biological process
1.29 3.76e-07 GO:0048523 negative regulation of cellular process
1.45 6.16e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.52 7.76e-07 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.21 8.16e-07 GO:0045165 cell fate commitment
1.51 1.09e-06 GO:2000026 regulation of multicellular organismal development
1.40 1.11e-06 GO:0031325 positive regulation of cellular metabolic process
1.46 1.30e-06 GO:0022008 neurogenesis
1.50 1.32e-06 GO:0051173 positive regulation of nitrogen compound metabolic process
1.43 1.61e-06 GO:0007154 cell communication
1.50 1.80e-06 GO:0007267 cell-cell signaling
1.26 2.28e-06 GO:0048522 positive regulation of cellular process
1.54 2.28e-06 GO:0051254 positive regulation of RNA metabolic process
1.52 2.59e-06 GO:0009790 embryo development
1.44 2.60e-06 GO:0042127 regulation of cell proliferation
1.46 4.05e-06 GO:0048699 generation of neurons
1.37 4.87e-06 GO:0051239 regulation of multicellular organismal process
1.63 5.81e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.27 6.77e-06 GO:0065008 regulation of biological quality
1.21 1.37e-05 GO:0060255 regulation of macromolecule metabolic process
1.59 1.45e-05 GO:0000904 cell morphogenesis involved in differentiation
1.63 1.70e-05 GO:0051094 positive regulation of developmental process
1.18 2.10e-05 GO:0051716 cellular response to stimulus
1.42 3.70e-05 GO:0048468 cell development
2.87 5.94e-05 GO:0070848 response to growth factor stimulus
3.49 7.46e-05 GO:0007602 phototransduction
1.19 8.15e-05 GO:0080090 regulation of primary metabolic process
1.82 1.30e-04 GO:0003002 regionalization
1.28 1.31e-04 GO:0007166 cell surface receptor linked signaling pathway
1.39 1.41e-04 GO:0032774 RNA biosynthetic process
1.17 1.70e-04 GO:0019222 regulation of metabolic process
1.52 1.72e-04 GO:0007186 G-protein coupled receptor protein signaling pathway
1.82 2.22e-04 GO:0007601 visual perception
1.82 2.22e-04 GO:0050953 sensory perception of light stimulus
1.40 3.01e-04 GO:0006351 transcription, DNA-dependent
1.45 3.14e-04 GO:0030182 neuron differentiation
1.67 3.89e-04 GO:0060284 regulation of cell development
1.49 3.93e-04 GO:0042060 wound healing
3.49 3.94e-04 GO:0009954 proximal/distal pattern formation
1.67 4.65e-04 GO:0001501 skeletal system development
1.58 4.93e-04 GO:0007409 axonogenesis
1.61 5.02e-04 GO:0009792 embryo development ending in birth or egg hatching
1.56 6.23e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.17 8.76e-04 GO:0031323 regulation of cellular metabolic process
1.38 8.96e-04 GO:0009611 response to wounding
1.64 9.21e-04 GO:0007411 axon guidance
1.70 9.37e-04 GO:0061061 muscle structure development
1.55 9.43e-04 GO:0048812 neuron projection morphogenesis
1.46 9.59e-04 GO:0032989 cellular component morphogenesis
1.60 9.84e-04 GO:0043009 chordate embryonic development
1.47 1.11e-03 GO:0000902 cell morphogenesis
1.20 1.23e-03 GO:0009889 regulation of biosynthetic process
1.47 1.35e-03 GO:0048666 neuron development
1.50 1.36e-03 GO:0008284 positive regulation of cell proliferation
1.22 1.56e-03 GO:0042221 response to chemical stimulus
1.67 1.62e-03 GO:0030029 actin filament-based process
1.38 1.74e-03 GO:0040011 locomotion
2.97 1.83e-03 GO:0009583 detection of light stimulus
1.63 2.69e-03 GO:0022603 regulation of anatomical structure morphogenesis
2.99 2.98e-03 GO:0071363 cellular response to growth factor stimulus
1.49 2.99e-03 GO:0007417 central nervous system development
1.20 3.16e-03 GO:0031326 regulation of cellular biosynthetic process
1.20 3.22e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.65 3.94e-03 GO:0007423 sensory organ development
1.57 4.10e-03 GO:0048598 embryonic morphogenesis
1.60 4.12e-03 GO:0045597 positive regulation of cell differentiation
1.24 4.91e-03 GO:0048583 regulation of response to stimulus
1.20 5.57e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.69 5.66e-03 GO:0030036 actin cytoskeleton organization
1.19 7.00e-03 GO:0010468 regulation of gene expression
1.47 7.13e-03 GO:0048585 negative regulation of response to stimulus
1.47 7.77e-03 GO:0032990 cell part morphogenesis
1.70 8.02e-03 GO:0048568 embryonic organ development
1.47 8.07e-03 GO:0048858 cell projection morphogenesis
1.47 8.70e-03 GO:0031175 neuron projection development
1.84 9.82e-03 GO:0009952 anterior/posterior pattern formation
1.50 1.03e-02 GO:0032583 regulation of gene-specific transcription
1.46 1.08e-02 GO:0006935 chemotaxis
1.46 1.08e-02 GO:0042330 taxis
2.07 1.17e-02 GO:0042176 regulation of protein catabolic process
1.16 1.23e-02 GO:0016043 cellular component organization
1.62 1.58e-02 GO:0048545 response to steroid hormone stimulus
1.86 1.59e-02 GO:0034330 cell junction organization
1.30 1.61e-02 GO:0010646 regulation of cell communication
1.28 1.84e-02 GO:0002376 immune system process
1.74 1.86e-02 GO:0007517 muscle organ development
1.36 1.89e-02 GO:0007155 cell adhesion
1.36 1.89e-02 GO:0022610 biological adhesion
1.18 1.97e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 2.03e-02 GO:0050878 regulation of body fluid levels
1.90 2.38e-02 GO:0030162 regulation of proteolysis
1.54 2.57e-02 GO:0007389 pattern specification process
1.38 2.66e-02 GO:0009719 response to endogenous stimulus
2.21 2.74e-02 GO:2000027 regulation of organ morphogenesis
2.35 3.08e-02 GO:0009582 detection of abiotic stimulus
1.38 3.34e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.22 3.59e-02 GO:0003008 system process
1.44 3.67e-02 GO:0007010 cytoskeleton organization
1.30 3.68e-02 GO:0009892 negative regulation of metabolic process
1.82 3.76e-02 GO:0009416 response to light stimulus
1.15 3.88e-02 GO:0071840 cellular component organization or biogenesis
1.44 3.95e-02 GO:0007599 hemostasis
1.43 4.62e-02 GO:0007596 blood coagulation
1.43 4.62e-02 GO:0050817 coagulation
1.71 4.77e-02 GO:0048732 gland development
1.67 4.86e-02 GO:0043193 positive regulation of gene-specific transcription
1.86 4.88e-02 GO:0034329 cell junction assembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 2.65e-11 GO:0044421 extracellular region part
1.33 7.08e-10 GO:0005576 extracellular region
1.27 3.58e-07 GO:0044459 plasma membrane part
1.54 7.33e-07 GO:0030054 cell junction
1.46 1.10e-06 GO:0005615 extracellular space
1.75 1.30e-06 GO:0005578 proteinaceous extracellular matrix
1.67 2.52e-06 GO:0031012 extracellular matrix
1.54 3.57e-04 GO:0045202 synapse
1.83 5.48e-04 GO:0005882 intermediate filament
1.69 7.67e-04 GO:0016323 basolateral plasma membrane
1.58 8.97e-04 GO:0044433 cytoplasmic vesicle part
1.86 1.01e-03 GO:0005912 adherens junction
1.81 1.22e-03 GO:0070161 anchoring junction
1.34 1.50e-03 GO:0042995 cell projection
1.25 1.86e-03 GO:0005856 cytoskeleton
1.99 2.30e-03 GO:0030055 cell-substrate junction
2.51 3.55e-03 GO:0034774 secretory granule lumen
1.13 4.28e-03 GO:0005886 plasma membrane
1.69 4.60e-03 GO:0045111 intermediate filament cytoskeleton
2.11 4.66e-03 GO:0045095 keratin filament
1.49 4.91e-03 GO:0009986 cell surface
1.13 5.47e-03 GO:0071944 cell periphery
2.41 8.33e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.45 9.04e-03 GO:0031093 platelet alpha granule lumen
2.30 1.00e-02 GO:0031091 platelet alpha granule
1.54 1.05e-02 GO:0015629 actin cytoskeleton
2.32 1.83e-02 GO:0031983 vesicle lumen
1.85 2.05e-02 GO:0044420 extracellular matrix part
1.67 2.33e-02 GO:0030424 axon
1.86 3.50e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.72 3.56e-14 GO:0043565 sequence-specific DNA binding
1.52 2.98e-11 GO:0030528 transcription regulator activity
1.50 4.34e-10 GO:0001071 nucleic acid binding transcription factor activity
1.50 4.34e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 3.86e-07 GO:0005102 receptor binding
1.12 4.57e-07 GO:0005515 protein binding
1.55 7.67e-07 GO:0005198 structural molecule activity
1.57 2.48e-03 GO:0003779 actin binding
1.63 1.12e-02 GO:0046982 protein heterodimerization activity
1.39 1.79e-02 GO:0008092 cytoskeletal protein binding
2.32 3.20e-02 GO:0051015 actin filament binding
1.05 4.07e-02 GO:0005488 binding